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Note #28004 by gptulvutpv 30/12/2013 @ 20:06

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This Sunday, July 8, 2012 photo shows Gammagard, a treatment that is being tested for Alzheimer's disease, at the home of a patient in New York. Three treatments, including Bapineuzumab and Solanezumab, being tested for the disease are antibodies - proteins made by the immune system that promote clearance of amyloid, the stuff Doudoune Parajumpers Kodiak that forms the plaque. (AP Photo/Seth Wenig)We're about to find out if there will be a way anytime soon to slow the course of Alzheimer's disease. Results are due within a month or so from key studies of two drugs that aim to clear the sticky plaque gumming up patients' brains.A pivotal study of doudoune parajumpers occasion a third drug will end later this year, and results from a small,doudoune parajumper, early test of it will be reported next week at an Alzheimer's conference in Vancouver, British Columbia.These three treatments are practically the "last men standing" in late-stage trials, after more than a decade of failed efforts to develop a drug to halt the mind-robbing disease. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.Experts say that if these fail, drug companies may pull out of the field in frustration, leaving little hope for the millions of people with the disease. An estimated 35 million people worldwide have dementia, which includes Alzheimer's. In the U.S., experts say about 5 million have Alzheimer's.The three treatments parajumpers homme being tested are not even drugs in the traditional, chemical sense. They are antibodies ? proteins made by the immune system that promote clearance of amyloid, the stuff that forms the plaque.It's a strategy with a checkered history, and scientists aren't even sure that amyloid causes Alzheimer's or that removing it will do any good in people who already have symptoms. But there are some hopeful signs they may be on the right track."Everybody in the field is probably holding their breath that there is something positive to come out of these trials," said Dr. Ronald Petersen, director of the Mayo Clinic's Alzheimer's Disease Research Center."It may not be a home run" in terms of improving memory and cognition, but if brain imaging or spinal fluid tests show the drugs are hitting their target, "they will be regarded as successes," he said.William Thies, scientific director of the Alzheimer's Association,doudoune parajumpers femme pas cher, agreed.Even if there is just a small effect, "that would be a huge finding because that would let you know you had a drug that worked," he said. It then could be tried as a preventive medicine or given earlier in the course of the disease when it may have more impact.The three drugs and their developers are:?Bapineuzumab (bap-ih-NOOZ-uh-mab), by Pfizer Inc. and Johnson & Johnson's Janssen Alzheimer Immunotherapy unit.?Solanezumab (sol-ah-NAYZ-uh-mab), by Eli Lilly & Co.?Gammagard, by Baxter International Inc.All are given as periodic intravenous infusions; some companies are trying to reformulate them so they could be given as shots. If a major study shows that one of the drugs works, there will be a huge effort to make it more convenient and practical, Thies predicted.Still, it would probably be very expensive.The first two on the list are lab-made, single antibodies against amyloid. Gammagard is intravenous immune globulin, or IVIG ? multiple, natural antibodies culled from blood. Half a dozen companies already sell IVIG to treat immune system and blood disorders. It takes 130 plasma donations to make enough to treat one patient for a year.Treating Alzheimer's with doudoune parajumpers boutique IVIG would cost $2,000 to $5,000 every two weeks, depending on the patient's weight, said Dr. Norman Relkin, head of a memory disorders program at New York-Presbyterian Hospital/Weill Cornell Medical Center. He consults for some drugmakers and has patents for tests that measure amyloid.Relkin is also leading a late-stage, 400-patient study of Gammagard that will wrap up late this year. A much smaller, earlier study he led showed less brain shrinkage among people receiving the drug than among those getting dummy infusions."It was so startling that I sent it to two laboratories for independent verification," Relkin said.Next week, at the Alzheimer's Association International Conference in Canada, Relkin will give a three-year progress report on 16 patients out of the original 24 enrolled in that earlier study.Jason Marder is among them. The New York City man, who turned 70 on Tuesday, was diagnosed with Alzheimer's more than eight years ago."It was devastating," said his wife, Karin Marder. "I thought, 'Our life is over together as a couple.' But in fact it really has not been, and I have to attribute this really to the clinical trial."In the roughly five years that her husband has taken Gammagard, there has been decline in his health, but it is minimal and the kind of slowing down you might expect

Note #28003 by biyhhmsmgmd 30/12/2013 @ 19:58

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WICHITA, Kan. (AP) ? Hawker Beechcraft wants to pay eight senior executives more than $5.3 million in bonuses as it tries to emerge from bankruptcy, but the request was challenged Monday by the Justice Department's bankruptcy watchdog agency and mocked by the company's machinist union.The Kansas-based airplane maker hasn't shown that its proposed bonus plan is not a "disguised retention plan," U.S. Trustee Tracy Hope Davis argued in documents filed in bankruptcy court in New York. Bonus plans are allowed but must do more than simply reward managers for staying during a bankruptcy reorganization.Hawker Beechcraft calls the bonuses an incentive award. The company said the plan was developed to recognize the critical role certain employees have in the bankruptcy process,Michael Kors Bags On Sale, arguing that their continued employment is essential to the company's ongoing business operations and restructuring."The plans are consistent with our commitment to emerging from the restructuring process in the strongest operational and financial position possible," the company said in a statement Monday.Davis argued there must be other factors such as "challenging standards" or "high hurdles" for debtors to overcome before they can be paid bonuses, and that Hawker Beechcraft did not meet those standards.The U.S. Trustee Program is a division of the Justice Department whose mission is to oversee bankruptcy Michael Kors Bags cases and maintain their integrity. A bankruptcy court hearing is scheduled for Thursday.The International Association of Machinists and Aerospace Workers said it plans to formally file an objection to the executive bonuses before the hearing."You got to be kidding me. Bonuses? And you know, really Site Michael Kors when I look at the company that owns Hawker Beechcraft, Goldman Sachs ? and what the country went Michael Michael Kors Bags through with them and bonuses ? I guess I Michael Kors Uk shouldn't be surprised," said Matt McKinnon, legislative and political director for the machinists union.Hawker Beechcraft Corp.,Michael Kors Outlet, based in Wichita,Michael Kors Handbags Outlet, is owned by Onex Partners and GS Capital Partners, a Goldman Sachs private equity fund. It has struggled with the sluggish business jet market more than other plane makers because it was purchased in a highly leveraged deal at the peak of the Michael Kors Bags Uk general aviation market, just before the market tanked.The company filed for bankruptcy protection in May. The court has approved exclusive talks with a Chinese firm that has offered nearly $1.8 billion to purchase the company's business jet and general aviation operations.The amount of the proposed bonuses for each manager are based on a formula that takes into account each executive's salary, the timing of the bankruptcy reorganization and whether Hawker Beechcraft emerges as a stand-alone entity or is sold to a third party.For example, management bonuses would be reduced by 25 percent of each participant's base salary for each $100 million in purchase price below the $1.79 billion deal offered by Beijing-based Superior Aviation Beijing Co.The highest potential bonus would be $1.26 million paid to Hawker Beechcraft Chairman Bill Boisture. Others receiving lesser bonuses would be various vice presidents in charge of operations, human resources, engineering, global customer support and customers, as well as the general counsel and chief financial officer. (Copyright 2012 Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)Featured Video NewsBusted 10/29/13Serious vs Solemn by John CleeseSNL Hacks Up HealthCare.gov Michael Kors Bags On Sale E-Brief

Note #28002 by biyhhmsmgmd 30/12/2013 @ 19:58

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Pedestrians walk outside a pawn shop offering money for gold, in Athens, on Monday, Aug. 20, 2012. Greece's Michael Kors Wallets finance officials are seeking to finalize euro 11.5 billion in spending cuts necessary for it to continue receiving the international funding that is protecting it from bankruptcy. (AP Photo/Petros Giannakouris)After their holidays spent soaking up the August sun,Michael Kors Outlet, Europe's political leaders are bracing themselves for storm clouds this fall.The latest economic figures show that Europe is edging closer to recession, dragged down by the crippling debt problems of the 17 countries that use the euro.These debt troubles have tormented the eurozone for close to three years and so far have defied leaders' efforts to fix them. And the longer they take to resolve, the bigger they get.Leaders from France, Germany and Greece all meet later on this week in the latest round of shuttle diplomacy to attempt to put a lid on the eurozone's debt crisis.Six eurozone countries ? Greece, Spain, Italy, Cyprus, Portugal and Malta ? are already in recession and others look feeble.Europe's stumbling economy is hurting recovery in other parts of the world. The European Union recorded a gross domestic product last year of $15.5 trillion ? slightly more than the U.S.'s output. It is also a major source of sales for the world's leading companies. Any further economic problems would be felt in order books back in the U.S. and China.Forty percent of McDonald's global revenue comes from Europe ? more than it generates in the U.S. The company reported a 0.6 percent slump in meals served in Europe last month. Ford Motor Co. warned last week that auto industry sales in the region through July were the lowest in 17 years.The eurozone has already provided billion in loans and financial aid to keep Greece, Ireland and Portugal from defaulting on their debts. And now markets are worried that recession-hit Spain and Italy could soon be asking Buy Michael Kors for assistance. Meanwhile, public anger over austerity measures and unemployment is spreading, and a key court ruling on the eurozone's crucial new bailout fund is due in Germany."September is going to be extremely busy," said Antonio Barroso, an analyst with the Eurasia Group political risk consultancy. "The potential for negative news is definitely there."Here are some of the key events anticipated in the coming months that could alter the temperature and the tempo of Europe's financial crisis:GREECEGreece is in its fifth year of recession. The economy is likely to contract another 7 percent this year, and unemployment is nearing 24 percent. Debt inspectors from the organizations that oversee Greece's bailout program ? the "troika" of the International Monetary Fund, European Union and European Central Bank ? are set to return to Athens in early September to finalize yet another round of austerity measures.Greece has been kept afloat by bailouts from its European partners and the IMF since May 2010, after it found it impossible to pay off its debts on its own. The rescue loans came in exchange for harsh austerity measures and reforms to its public sector. The country's debt stands at more than ?00 billion ($369 billion), and the economy is struggling through a fifth year of recession with unemployment at above 23 percent.But the cash lifeline has been disrupted by months of political instability? that were resolved, for now, after two national elections ? during which the austerity and reform process lagged severely. As a result, the next ?1 billion installment,Michael Kors Bags, if approved by bailout creditors following a review of the country's finances, has been delayed until next month at the earliest.To qualify for that payment, Greece's eight-week-old coalition government must identify by the end of the month a new round of budget cuts worth ?1.5 billion for 2013 and 2014.Officials have said this is likely Cheap Michael Kors to include additional cuts in pensions and the initial sums paid out on retirement. Greece has also promised to reduce its 750,000-strong workforce in the civil service and the broader public sector by 150,000 by the end of 2015.Many in the country are worried that the continuing decline in living standards could result in a repeat of violent streets protests witnessed in recent years.If the troika finds Greece is not sticking to the terms of the bailout agreement,Michael Kors Totes, it could hold off vital funding, forcing the country into a chaotic default on its debt. This could push the country out of the eurozone, further destabilizing the region.Europe's Michael Kors Totes finance ministers meet Sept. 14 and 15 in Cyprus to discuss Greece and its prospects.SPAINThe first batches of a loan worth up to ?00 billion for Spain's debt-stressed banks are due to be sent to Madrid from the other 16 eurozone countries in the coming weeks, bringing some short-term relief for a country battling to avoid a

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MIAMI -- The flamboyant judge brought to fame in the fight over Anna Nicole Smith's remains says he believes someone is guilty of manslaughter in the starlet's death and second-guesses his own decision over where she is buried in a book to be released Tuesday.Larry Seidlin, the former Fort Lauderdale judge, is harshly critical of Smith's lawyer-turned-companion Howard K. Stern, and of the police investigations into the deaths of the Playboy Playmate and her son. But as provocatively titled as "The Killing of Michael Kors Online Outlet Anna Nicole Smith" is, Seidlin offers no evidence either death was anything more than the accidental drug overdoses they were deemed."I think enablers should be punished,Michael Kors Outlet," Seidlin writes, then refers directly to Stern. "How about keeping her off drugs while she was alive? He was with her every day; how about saying no ..."Then, the judge says, "we won't have all this celebrity blood on our hands."Seidlin presided over the six-day televised hearing into the fate of Smith's body, shortly after her February 2007 death. His jurisdiction was limited to control of Smith's body; Florida never Michael Kors Handbags Outlet charged anyone in Michael Kors Online Store connection with her death.Seidlin's hearing became a national obsession, with a cast of characters suited for reality TV. Bronx-born Seidlin, a former New York cab driver, was full of smart-alecky one-liners and nicknames for attorneys and witnesses. Dr. Joshua Perper, the medical examiner, became "Dr. Pepper" and lawyers were nicknamed "California" and "Texas," after their home states."I'm not going to talk about this case ever again," he promised at its close. But, of course, he did and he remained in the news, including the book Michael Kors Canada Outlet from Canada-based Transit Publishing, which specializes in celebrity biographies.In a phone interview Monday, Seidlin said he wrote the book because he was troubled by the deaths of Smith and her son. "When I was sitting in that trial," he said, "red flags were flying in front of me and I had a lot of sleepless nights."Seidlin has also signed a deal for a television show called "Psychic Court," in which he'll seek the input of tarot card readers, astrologers and other psychics to help him decide family court and small claims disputes. He said it was slated to premiere in Fall 2011. Los Angeles-based production company Mighty Oak Entertainment said it's shopping the show for syndication or cable.Meanwhile, Stern and two of Smith's doctors are scheduled Michael Kors Handbags Outlet to go on trial Aug. 4 on charges that they illegally funneled sedatives and opiates to the model. They have pleaded not guilty and are not charged with causing Smith's death.Seidlin says in the book that Stern "exercised a great amount of control over Anna Nicole by maintaining and reviewing her drug desires and addiction." He calls for reopening investigations into the death of her 20-year-old son, Daniel Smith, in September 2006 and of the model five months later, noting Stern was present at both. He says police bungled the original investigations.Stern's attorney, Steve Sadow, said "Any allegations made by Judge Seidlin against Howard K. Stern are truly unworthy of response."Much of Seidlin's book rehashes the Smith hearings, reprinting court transcripts with commentary mixed in. He tries to burnish his image as a judge, but also appears to question the one decision he made in the case."I want her buried with her son in the Bahamas,Michael Kors Outlet Bags," Michael Kors Factory Outlet he said through tears at the time. "I want them to be together."Throughout the book, though, Seidlin is sympathetic to Smith's mother, Virgie Arthur, who fought for her estranged daughter's burial in her native Texas. He calls for her reburial there, or possibly in California,Michael Kors Outlet Online Store, saying "Her soul and Danny's soul need to be placed on sacred ground in the Lone Star state with people who grew up with her and loved her in her simpler days."

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